Unveiling Neural Circuit Dysfunction

in Neuropsychiatric Disorders

Exploit a circuit-specific gene manipulation approach in vivo to investigate a common pathogenic brain network, which drives a specific behavioral abnormality

Circuit selective gene manipulation

Deciphering gene effects on a neural circuit by circuit-selective Ca2+ imaging and optogenetic circuit manipulation

Analyzing neural circuit activity in circuit-selective mutant mice during behaviors in real-time.

Electrophysiological neural circuit analysis in circuit-selective mutant mice.